Agnirva Space Premier League - Expedition #30901: Investigating Telomere Biology in Space: Genes in Space-10

Genes in Space-10 took student research to new heights—literally—by exploring how microgravity affects the protective caps at the ends of chromosomes known as telomeres. High school student Pristine Onuoha designed this project to study the activity of a key enzyme, telomerase, which maintains telomere length and plays a role in aging and cancer.

In the harsh environment of space, exposure to radiation and microgravity can accelerate the shortening of telomeres. This can impact cell aging and increase the risk of disease. Genes in Space-10 aimed to determine whether the gene for telomerase is turned on or off during spaceflight and how its activity changes in orbit compared to Earth.

The experiment used advanced molecular biology tools onboard the ISS, including the miniPCR device, to isolate and amplify specific genetic material. By monitoring gene expression in real time, researchers could assess the potential of telomerase as a biomarker for cellular health during space missions.

Genes in Space-10 not only advanced our understanding of molecular aging in space but also showcased the incredible contributions young minds can make to space science. The project highlighted the feasibility of performing genetic analysis in microgravity, opening the door to future space-based biomedical research.

Join the Agnirva Space Internship Program to embark on your own journey of genetic discovery and space innovation.

Get certified with over 100 hours of immersive, self-paced learning in astronomy, cosmology, space technology, and climate science through the Agnirva Space Internship Program. Join, complete virtual projects, and earn a digital certificate to showcase your space fluency in interviews, resumes, and beyond.