Agnirva Space Premier League - Expedition #30903: Detecting Viral Infections in Space: Insights from Genes in Space-12

Genes in Space-12 tackled a vital challenge for astronaut health: identifying and diagnosing viral infections in the unique conditions of space. The project, led by students Isabelle Chuang and Julia Gross with support from Harvard and miniPCR bio scientists, focused on developing a protocol to detect latent viral reactivation in space.

In space, stress and a weakened immune system can cause dormant viruses, like herpesviruses, to reactivate. This poses a risk for long-term missions where medical help is limited. Genes in Space-12 aimed to create a reliable test for viral mRNA that could be used aboard the ISS, using tools like the miniPCR and fluorescence-based detection.

The experiment simulated a diagnostic workflow astronauts could follow. By amplifying and identifying viral RNA signatures, the team evaluated how feasible it would be to diagnose infections in microgravity—without needing to return samples to Earth.

This breakthrough laid the foundation for point-of-care diagnostics in orbit, essential for future moon and Mars missions. It also showed that complex molecular testing is possible in space, opening doors for in-flight monitoring of many health conditions.

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