Agnirva Space Premier League - Expedition #30908: Genes in Space-6: Uncovering the Impact of Spaceflight on Immune Genes

Genes in Space-6, a standout student-led experiment, continued the mission of investigating DNA behaviors in space. Developed by a talented team from Amplyus—David Li, Michelle Sung, Aarthi Vijayakumar, and Rebecca Li—this experiment explored how spaceflight impacts gene expression related to the immune system.

Astronauts often experience a weakened immune response in space, leading to increased vulnerability to infections. Genes in Space-6 focused on the expression of specific T-cell genes to better understand this phenomenon. Using miniPCR and other molecular tools, the student team examined whether certain immune-related genes were activated or suppressed under microgravity conditions.

The research aimed to identify potential biomarkers that could serve as early indicators of immune system degradation in astronauts. By monitoring these markers in real time aboard the ISS, the study offered a path toward better health monitoring and intervention strategies for long-duration missions.

This experiment not only contributed to astronaut health but also opened new pathways for biotechnology applications in space. The success of the study validated the ISS as a viable lab for advanced genetic research and highlighted how young scientists could contribute meaningfully to real-world scientific progress.

By focusing on gene expression rather than just the presence of genes, Genes in Space-6 added nuance to our understanding of human biology in space. It laid groundwork for future research into adaptive responses of the immune system, with wide-reaching implications for healthcare both in space and on Earth.

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