Agnirva Space Premier League - Expedition #30911: Genes in Space-9: Student Scientists Explore DNA Repair in Space

The International Space Station has become a beacon for educational experiments that expand scientific understanding while inspiring future explorers. One such mission, Genes in Space-9, led by student researcher Selin Kocalar, tackled a fundamental biological question: how does microgravity impact DNA repair mechanisms?

DNA damage is a common challenge for astronauts due to higher exposure to cosmic radiation. If DNA repair processes are impaired in space, it could lead to health issues over long-duration missions. Genes in Space-9 aimed to explore how specific repair pathways function in microgravity, particularly the process known as DNA mismatch repair.

Using the miniPCR DNA amplification technology, astronauts onboard the ISS were able to amplify and analyze DNA samples in real time. This hands-on experimentation in orbit helped identify changes in genetic behavior that occur when Earth’s gravity is absent. These insights are critical for assessing risks to astronaut health and devising strategies for future deep-space travel.

The project highlights the importance of student-driven initiatives in advancing our understanding of space biology. Through competitions and mentorship, young scientists are given a platform to conduct meaningful research that can influence real-world policies and technologies.

Not only does Genes in Space-9 deepen our grasp of genetic responses to spaceflight, but it also demonstrates how miniaturized biotechnology tools can be used effectively in remote environments. The practical implications stretch beyond space—portable PCR systems may be utilized in rural healthcare settings, disaster zones, or even future Martian colonies.

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