Agnirva Space Premier League - Expedition #31150: Spinning Mice in Space: Unlocking How Artificial Gravity Shapes Physiology and Aging

The experiment titled 'Adaptation of Mouse Systems Physiology to Artificial Gravity via Centripetal Acceleration: Timing, Metabolism & Aging' explores how living organisms, specifically mice, respond to artificial gravity in a space environment. Conducted on the International Space Station (ISS), this NASA-led project uses a rotating centrifuge to simulate gravity and observe physiological changes in metabolism, aging, and biological systems over time.

When astronauts spend extended periods in microgravity, their bodies undergo significant changes—bone loss, muscle atrophy, altered cardiovascular function, and more. To counter these effects, artificial gravity is a promising solution. This experiment simulates Earth-like gravity through centrifugal force, helping us understand whether it can help maintain healthy body function during space missions.

The research team examined how timing and duration of artificial gravity exposure impact bodily systems, particularly aging and metabolism. Mice were placed in specialized habitats that spun at controlled speeds, creating varying levels of gravity. Scientists monitored their food intake, physical activity, sleep patterns, hormonal changes, and molecular responses in tissues.

Key findings are expected to include whether artificial gravity can slow age-related decline in space and improve metabolic stability. The implications go far beyond rodents. These insights could guide strategies for keeping astronauts healthy on long journeys to Mars or the Moon—and even help us understand aging on Earth.

The experiment represents collaboration between NASA centers, Japanese and American researchers, and commercial partners. Together, they are building a blueprint for artificial gravity use, potentially revolutionizing future spaceflight design.

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