Agnirva Space Premier League - Expedition #31189: Unlocking DNA Secrets in Space: The PCG-DNA-Ligasa Experiment

The PCG-DNA-Ligasa experiment represents a critical step forward in understanding how DNA behaves in space. Conducted aboard the International Space Station (ISS), this study aimed to crystallize biological macromolecules, specifically DNA ligase, under microgravity conditions. DNA ligase is an enzyme that plays an essential role in DNA replication and repair. Understanding its structure in minute detail can help scientists develop new therapies for genetic disorders and improve DNA-based technologies. Microgravity provides a unique environment where crystals grow more uniformly, allowing for more accurate structural analysis. This investigation, carried out across several ISS expeditions, enabled researchers to form biocrystalline films that are challenging to produce on Earth. The results of this experiment have wide-ranging implications for biotechnology and molecular biology. By improving our ability to map enzymes like DNA ligase, the experiment paves the way for advancements in medicine and DNA engineering, potentially revolutionizing how we treat diseases and engineer new biological systems.

Get certified with over 100 hours of immersive, self-paced learning in astronomy, cosmology, space technology, and climate science through the Agnirva Space Internship Program. Join, complete virtual projects, and earn a digital certificate to showcase your space fluency in interviews, resumes, and beyond.