Agnirva Space Premier League - Expedition #31198: Space-Grown Crystals of KDU Enzyme: Exploring New Frontiers in Biotechnology

The PCG-KDU experiment took aim at the enzyme KDU—short for 2-keto-3-deoxygluconate aldolase—an important molecule in the metabolism of sugars in some bacteria. By studying this enzyme, scientists aim to understand fundamental life processes and how they might be exploited for biotechnological applications.

Earth-based crystallization of KDU had always faced challenges due to environmental inconsistencies and gravitational effects. But the ISS provided a microgravity laboratory ideal for growing large, pure, and defect-free crystals.

During Expeditions 39/40 and 41/42, KDU protein samples were sent to space. The goal: produce high-quality crystals that can be analyzed using X-ray diffraction techniques to reveal their atomic structure.

Understanding the KDU enzyme could lead to better bioconversion processes, where microbes are used to produce biofuels or degrade waste. Structural knowledge of such enzymes opens doors for industrial and pharmaceutical innovations.

Space-based crystallography is proving to be a powerful tool, and PCG-KDU is another step forward in that journey.

Join the Agnirva Space Internship Program

Get certified with over 100 hours of immersive, self-paced learning in astronomy, cosmology, space technology, and climate science through the Agnirva Space Internship Program. Join, complete virtual projects, and earn a digital certificate to showcase your space fluency in interviews, resumes, and beyond.