Agnirva Space Premier League - Expedition #31313: Unraveling the Space Secrets of Bone Health: JAXA’s Proteome Quest on the ISS

Understanding how microgravity affects human bones is essential for long-duration space travel. The experiment titled 'Medical Proteome Analysis of Osteoporosis and Bone Mass-related Proteins' led by Dr. Hisashi Hirano aims to uncover the molecular secrets behind bone loss in space using the Kibo Japanese Experiment Module on the ISS. In space, astronauts suffer bone density loss due to the lack of gravitational stress. This study dives into the proteome—the entire set of proteins expressed in bone tissue—to identify changes in protein expression that could explain the onset of osteoporosis in microgravity.

By leveraging cutting-edge proteomics technologies, researchers at the Yokohama City University, supported by the Japan Aerospace Exploration Agency (JAXA), collected biological samples over multiple ISS expeditions. These samples were preserved and analyzed to trace variations in proteins linked to bone metabolism, remodeling, and structural integrity. The goal was to identify specific biomarkers and pathways involved in bone degradation. With this data, scientists can better design countermeasures, like targeted medications or dietary plans, to protect astronaut health.

Moreover, findings from space could also have applications on Earth, where millions suffer from osteoporosis, especially among the elderly. This experiment bridges the gap between space exploration and terrestrial medicine, opening doors for innovative treatments.

Join the Agnirva Space Internship Program

Get certified with over 100 hours of immersive, self-paced learning in astronomy, cosmology, space technology, and climate science through the Agnirva Space Internship Program. Join, complete virtual projects, and earn a digital certificate to showcase your space fluency in interviews, resumes, and beyond.