Agnirva Space Premier League - Expedition #31437: Mice, Genes, and Reproduction in Space: How JAXA Investigates Life’s Blueprint Beyond Earth

What happens to life at the molecular level when exposed to space? JAXA’s experiment involving transcriptome and germ-cell development analysis of mice aboard the ISS offers fascinating insights into how spaceflight affects gene expression and reproductive health.

Led by Drs. Satoru Takahashi and Takashi Shiga, this study used cutting-edge transcriptomics—the study of RNA transcripts—to investigate how genes turn on or off in space. The experiment also examined the development of germ cells, the precursors to eggs and sperm.

Carried out over Expeditions 45/46 and 47/48, researchers aimed to determine whether the space environment causes lasting genetic or reproductive changes. They compared tissues from spaceflown mice with Earth-based controls, examining organs including the brain, liver, and reproductive system.

Their findings help answer big questions: Can mammals reproduce safely in space? How does radiation or microgravity affect DNA and fertility? These answers are critical for planning future human colonies on the Moon or Mars.

Through this mouse model, scientists gained a clearer picture of how space influences life at its most fundamental level.

Join the Agnirva Space Internship Program

Get certified with over 100 hours of immersive, self-paced learning in astronomy, cosmology, space technology, and climate science through the Agnirva Space Internship Program. Join, complete virtual projects, and earn a digital certificate to showcase your space fluency in interviews, resumes, and beyond.