Agnirva Space Premier League - Expedition #31442: Fighting Viruses in Space: How Microgravity Impacts Innate Immunity

When we think about spaceflight, we often imagine floating astronauts and stunning views of Earth. But behind the scenes, their immune systems face real challenges. Dr. Roberto Garofalo at the University of Texas Medical Branch explored how space affects innate immunity—our body’s first line of defense against infections—specifically for respiratory viruses.

The study used mouse models aboard the ISS during Expedition 25/26. Researchers examined how microgravity alters immune signaling, white blood cell activity, and the expression of key antiviral genes. They found that space conditions reduced the mice’s ability to mount a strong innate response to respiratory viruses.

This has huge implications for astronaut safety, especially during long missions when immediate medical care isn't available. The findings could also translate into new treatments for patients with weakened immune systems on Earth. By understanding how gravity influences immunity, we can develop better ways to fight infections in any environment.

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