Agnirva Space Premier League - Expedition #31467: Understanding Joint Health in Space: The CBS Micro-Physiological System Experiment

Microgravity affects more than just muscles and bones—it also impacts joints. The Cartilage–Bone–Synovium (CBS) Micro-Physiological System (MPS) experiment, developed by Techshot, Inc., and supported by NASA, seeks to understand how these complex tissues behave in space.

Led by Dr. Alan Grodzinsky at the Center for Biomedical Engineering in Cambridge, this experiment simulates human joint tissues using a miniature lab-on-a-chip. This system mimics the interaction between cartilage, bone, and synovium—the three main tissues in our joints. By observing how they react to the absence of gravity, researchers can uncover changes that may affect joint health.

Why is this important? Prolonged exposure to microgravity can accelerate joint degeneration, which is a concern for astronauts on long missions. The CBS MPS allows scientists to study cellular responses, inflammation, and tissue degradation in space-like conditions. It also enables testing potential therapies that could prevent joint damage.

Conducted during Expedition 59/60, this experiment opens the door to innovative treatments not only for astronauts but also for people on Earth suffering from arthritis or joint injuries. The ability to study and manipulate these tissues in a controlled, gravity-free setting is a breakthrough in biomedical research.

Ultimately, the CBS MPS is more than a space experiment—it's a step toward healthier joints for everyone, on Earth and beyond.

Join the Agnirva Space Internship Program

Get certified with over 100 hours of immersive, self-paced learning in astronomy, cosmology, space technology, and climate science through the Agnirva Space Internship Program. Join, complete virtual projects, and earn a digital certificate to showcase your space fluency in interviews, resumes, and beyond.