Agnirva Space Premier League - Expedition #31792: Genes in Space: Investigating One-Carbon Metabolism and Astronaut Health

As space travel becomes longer and more ambitious, understanding how individual genetics impact health is essential. The experiment 'One-Carbon Metabolism: Expanded Polymorphism Evaluation' dives deep into this question, expanding on earlier research into how variations in genes influence astronauts’ response to microgravity.

Led by Dr. Scott Smith at NASA’s Johnson Space Center, this research builds on previous studies of one-carbon metabolism—a critical pathway that involves folate and vitamin B12 and affects DNA synthesis, repair, and methylation. These processes are essential for maintaining cellular function and health in the extreme conditions of space.

This expanded evaluation focused on identifying additional polymorphisms (genetic variations) and understanding how they correlate with health outcomes during spaceflight. The results help refine predictive health models, allowing NASA to develop personalized nutrition and countermeasure plans for each astronaut.

Ultimately, these findings not only aid in keeping astronauts healthy during missions but also contribute to precision medicine on Earth. As we aim for deep space exploration, understanding how genes interact with spaceflight environments is key to mission success.

Join the Agnirva Space Internship Program

Get certified with over 100 hours of immersive, self-paced learning in astronomy, cosmology, space technology, and climate science through the Agnirva Space Internship Program. Join, complete virtual projects, and earn a digital certificate to showcase your space fluency in interviews, resumes, and beyond.