Agnirva Space Premier League - Expedition #32391: Fat Cells in Space: Investigating the Healing Powers of Stromal Vascular Fractions

What happens to the healing potential of fat-derived cells when gravity is no longer in the equation? The experiment led by H. Paek during Expeditions 27 and 28 aboard the ISS aimed to answer this by studying stromal vascular fraction (SVF) cells — a rich mix of stem and progenitor cells derived from human adipose (fat) tissue.

SVF cells are known for their trophic effects, meaning they can secrete factors that support cell survival, growth, and tissue repair. This makes them invaluable in regenerative medicine. But their behavior in microgravity was largely unknown before this study.

The experiment examined how microgravity affects the ability of these cells to support healing processes. Researchers observed gene and protein expression changes that suggested a modified secretion profile under microgravity. These findings are crucial for both space medicine and for improving stem cell therapies on Earth.

Understanding how SVF cells behave in space could lead to breakthroughs in treating injuries, improving recovery after surgeries, and enhancing the quality of life for people with degenerative diseases.

Join the Agnirva Space Internship Program

Get certified with over 100 hours of immersive, self-paced learning in cosmology, space technology, and climate science through the Agnirva Space Internship Program. Join, complete virtual projects, and earn a digital certificate to showcase your space fluency in interviews, resumes, and beyond.